Phase 3 will provide an opportunity to collect additional field data from a wider group of cattle to inform options to optimise the performance and reliability of the DIVA (Detect Infected among Vaccinated Animals) test.
A cattle vaccine for bovine TB, along with the new DIVA Skin Test, brings hope to many farmers in the fight for TB eradication.
Benefit herds for generations to come
Vaccinating cattle against TB has the potential to protect individual animals and halt disease spread within herds and populations.
The DIVA Skin Test (DST-F) is an innovative tool for bTB testing in vaccinated cattle populations. Specifically, the DST-F test is designed to distinguish between cattle vaccinated with the BCG (Bacillus Calmette-Gu茅rin) vaccine and those infected with Mycobacterium Bovis, the bacterium which causes bTB infection.
Head of Defra TB Programme and Deputy UK CVO Ele Brown said: 鈥淭his next step in the ongoing field trials reflects our commitment to providing robust assurances of test performance for our farmers and vets.
鈥淎long with colleagues in Scotland and Wales, we will continue to assess how this potential new tool could be deployed and provide the greatest possible benefit to our herds for generations to come.鈥�
鈥淚f we are to stand any chance of eradicating this devastating disease, it is vital that we have access to all the tools that have been proven to reduce bTB in our cattle and our countryside.鈥�
NFU President Tom Bradshaw
The results of the latest field trial of 300 vaccinated and 300 unvaccinated cattle offer confidence in safety to support a future marketing authorisation application. However, results indicate that there is still a need to collate further data on test performance.
Two animals on a participating farm exhibited reactions equal to or above the proposed positive cutoff point of > 2mm. Many factors may have induced this reaction, and this next phase of testing protocol assessment aims to enhance diagnostic accuracy across settings.
The criteria for the next phase will aim to inform practical disease control solutions for bTB in vaccinated herds.
NFU President Tom Bradshaw said: 鈥淚f we are to stand any chance of eradicating this devastating disease, it is vital that we have access to all the tools that have been proven to reduce bTB in our cattle and our countryside; increased cattle testing, vaccination of badgers where viable and the culling of badgers where the disease is endemic.
鈥淭hese tools must include a workable vaccine for cattle and associated DIVA test. Both are needed, and they would represent a significant step forward in the fight against bTB, so it is essential that everything is done to make sure it is the most effective it can be when it is made available for use.
鈥淲e cannot afford to get this wrong. Further field trials are needed to help provide us with a vaccine for cattle that will play a vital role in the future eradication of this terrible disease.鈥�
Further information on the development of a CattleBCG vaccine and DIVA test can be found on the which will be updated in due course.
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